BPC-157

Key benefits

What to expect

Based on community reports and published research. Individual results vary significantly.

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Dosing protocols

Dosing information is sourced from published research and community protocols. This is not a recommendation. Consult a healthcare professional.

Overview

BPC-157 (Body Protection Compound-157) is a 15-amino-acid peptide originally isolated from human gastric juice. First studied in the early 1990s, it has accumulated over 100 published studies examining its effects on tissue repair, gut healing, and inflammation. Unlike many peptides, BPC-157 is stable in gastric acid, which has led to interest in both injectable and oral forms. It remains a research compound without FDA approval, but has become one of the most widely discussed peptides in the biohacking and sports recovery communities.

How it works

BPC-157 appears to work through multiple pathways. Research indicates it upregulates growth factor expression (VEGF, EGF, and others), promotes angiogenesis (new blood vessel formation), and modulates the nitric oxide system. It has been shown to accelerate the formation of granulation tissue and collagen organisation in animal models. It also appears to interact with the dopaminergic system and has demonstrated effects on the gut-brain axis in preclinical studies.

Side effects

Research history

What the research says

The majority of BPC-157 research comes from animal studies, primarily in rats. These studies consistently demonstrate accelerated healing across multiple tissue types - tendons, ligaments, bone, muscle, and intestinal lining. A 2018 review in the Journal of Physiology-Paris noted its "consistent and reproducible" effects on angiogenesis and wound healing. Human clinical data remains extremely limited, with most evidence being preclinical or anecdotal. The peptide community often cites Dr. Predrag Sikiric's extensive body of work (University of Zagreb) which spans over 100 published studies.

BPC-157 and the gut

One of BPC-157's most distinctive properties is its stability in stomach acid. Unlike most peptides that are degraded by gastric enzymes, BPC-157 maintains its structure and biological activity when taken orally. Animal studies have shown it can heal inflammatory bowel disease (IBD), reduce gastric ulcers, and protect the gut lining from NSAID damage. This has made it of particular interest to those dealing with gut health issues, leaky gut, and NSAID-related gastric damage.

Reconstitution and storage

BPC-157 typically comes in 5 mg vials as a lyophilised (freeze-dried) powder. Reconstitute with 2 mL of bacteriostatic water for a concentration of 2.5 mg/mL (2500 mcg/mL). At a 250 mcg dose, this gives 10 units on a 100-unit insulin syringe and 20 doses per vial. Store reconstituted peptide in the refrigerator (2–8°C) and use within 4 weeks. Do not freeze once reconstituted.

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References

1. [1]Sikiric P, et al. "Brain-gut axis and pentadecapeptide BPC 157." Journal of Physiology-Paris, 2018.
2. [2]Seiwerth S, et al. "BPC 157 and standard angiogenic growth factors." Current Pharmaceutical Design, 2018.
3. [3]Chang CH, et al. "BPC 157 enhances tendon-to-bone healing." Journal of Orthopaedic Research, 2021.
4. [4]Vukojevic J, et al. "Pentadecapeptide BPC 157 and the central nervous system." Neural Regeneration Research, 2022.

Frequently asked questions

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