Glutathione
L-Glutathione (γ-Glutamylcysteinylglycine)
The master antioxidant your cells depend on
Glutathione is the body's most abundant antioxidant, found in every cell. It neutralises free radicals, supports detoxification, and declines significantly with age.
Admin routes
IV, Subcutaneous, Oral (liposomal)
Popularity
Medium
Side effects
Generally mild
Vendors
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Key benefits
What to expect
Immediate sense of energy and clarity
Improved skin brightness; reduced oxidative markers
Visible skin lightening/brightening (if goal)
Sustained antioxidant and detoxification benefits
Based on community reports and published research. Individual results vary significantly.
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Dosing protocols
General antioxidant support (oral)
250–500 mg liposomal
Once daily
Ongoing
Detoxification (IV)
600–1400 mg
Weekly
4–8 week cycles
Skin brightening
600–1200 mg IV or 500 mg oral
Weekly (IV) or daily (oral)
8–12 weeks
Dosing information is sourced from published research and community protocols. This is not a recommendation. Consult a healthcare professional.
Research status|Extensive human data - well-established biochemistry
Overview
Glutathione (GSH) is a tripeptide composed of glutamic acid, cysteine, and glycine. It is the most abundant intracellular antioxidant in the human body and is critical for detoxification, immune function, and cellular protection against oxidative stress. Glutathione levels decline with age, chronic illness, poor diet, and environmental toxin exposure. Supplementation via IV, injection, or oral (liposomal) forms has become a staple in longevity and functional medicine.
How it works
Neutralises free radicals and reactive oxygen species through electron donation. Acts as a cofactor for glutathione peroxidase and glutathione S-transferase enzymes. Regenerates vitamins C and E to their active forms. Plays a central role in phase II liver detoxification - conjugating toxins for excretion. Maintains cellular redox balance critical for immune cell function and DNA repair.
Side effects
Research history
First identified by J. de Rey-Pailhade
Chemical structure determined by Hopkins
Role in detoxification and liver function established
IV glutathione clinics emerge for wellness and skin brightening
Liposomal forms make effective oral supplementation practical
Oral vs IV glutathione
Standard oral glutathione is poorly absorbed - stomach acid and peptidases break it down before it reaches circulation. Liposomal glutathione wraps the molecule in phospholipid layers, dramatically improving bioavailability (some studies suggest comparable levels to IV administration). IV glutathione bypasses the gut entirely and achieves immediate high blood levels, but requires clinical administration. For most people, high-quality liposomal glutathione is the practical choice.
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References
- [1]Pizzorno J. 'Glutathione!' Integrative Medicine: A Clinician's Journal, 2014.
- [2]Richie JP, et al. 'Randomized controlled trial of oral glutathione supplementation on body stores of glutathione.' European Journal of Nutrition, 2015.
Frequently asked questions
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Supplies
Syringes, bac water, storage
Guides
How-to guides
Storage, reconstitution, and travel
Disclaimer: This guide is for educational and informational purposes only. It is not medical advice. The dosing protocols listed are sourced from published research and community reports and do not constitute a recommendation. Always consult a qualified healthcare professional before using any peptide. Check your local regulations regarding peptide purchase and use.