KPV
Lysine-Proline-Valine
The anti-inflammatory tripeptide derived from α-MSH
KPV is a tripeptide fragment of alpha-melanocyte-stimulating hormone with potent anti-inflammatory properties, particularly for gut inflammation.
Admin routes
Oral, Subcutaneous, Topical
Popularity
Medium
Side effects
Generally mild
AU vendors
0 rated
✓Key benefits
📈What to expect
Reduced gut inflammation markers
Improved digestive comfort; reduced bloating
Gut lining healing; improved bowel regularity
Significant reduction in inflammatory gut symptoms
Based on community reports and published research. Individual results vary significantly.
💊Dosing protocols
Gut inflammation (oral)
200–500 mcg
Once or twice daily
4–8 weeks
Systemic anti-inflammatory
200–500 mcg
Once daily (subcutaneous)
4–6 weeks
Dosing information is sourced from published research and community protocols. This is not a recommendation. Consult a healthcare professional.
Research status|Preclinical - animal studies with promising gut inflammation data
Overview
KPV (Lysine-Proline-Valine) is a C-terminal tripeptide fragment of alpha-melanocyte-stimulating hormone (α-MSH). Despite being only three amino acids, it retains the anti-inflammatory activity of the full α-MSH molecule without its melanogenic (tanning) effects. Research shows significant efficacy in reducing gut inflammation, making it of particular interest for inflammatory bowel disease (IBD), colitis, and general gut health.
⚙️How it works
Enters cells and inhibits NF-κB activation - a master regulator of inflammatory gene expression. By suppressing NF-κB, KPV reduces production of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6). In the gut, it has been shown to reduce mucosal inflammation, decrease immune cell infiltration, and promote epithelial barrier integrity.
⚡Side effects
📅Research history
Identified as the minimum anti-inflammatory fragment of α-MSH
α-MSH peptide class reviewed as new anti-inflammatory drug candidates
Landmark study demonstrates KPV attenuates colitis via NF-κB inhibition
Growing interest for IBD and autoimmune gut conditions
Adopted in functional medicine for gut healing protocols
KPV for gut health
KPV's most promising application is gut inflammation. Animal studies have shown it significantly reduces colitis severity, decreases inflammatory markers in gut mucosa, and promotes healing of intestinal epithelium. Because it's a small tripeptide that survives gastric acid (unlike most peptides), oral administration is viable - making it one of the few peptides that can act directly on gut tissue when taken orally.
References
- [1]Dalmasso G, et al. 'The tripeptide KPV attenuates experimental colitis by inhibiting NF-κB signaling.' Gastroenterology, 2008.
- [2]Luger TA, et al. 'α-MSH related peptides: a new class of anti-inflammatory and immunomodulating drugs.' Annals of the Rheumatic Diseases, 2007.
Frequently asked questions
Related peptides
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Use our free reconstitution calculator to work out syringe units for KPV.
Open CalculatorDisclaimer: This guide is for educational and informational purposes only. It is not medical advice. The dosing protocols listed are sourced from published research and community reports and do not constitute a recommendation. Always consult a qualified healthcare professional before using any peptide. Australian regulations classify many peptides as Schedule 4 (prescription-only) substances. Check current TGA guidelines before purchasing.