Melanotan 2

Key benefits

What to expect

Based on community reports and published research. Individual results vary significantly.

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Dosing protocols

Dosing information is sourced from published research and community protocols. This is not a recommendation. Consult a healthcare professional.

Overview

Melanotan 2 (MT-2) is a synthetic cyclic peptide analogue of alpha-melanocyte-stimulating hormone (α-MSH), originally developed at the University of Arizona in the 1990s for skin cancer prevention through UV-free tanning. It activates melanocortin receptors (MC1R through MC5R), producing broad effects: melanogenesis (skin darkening), increased libido (via MC4R in the brain), appetite suppression, and modulation of inflammatory pathways. MT-2 is enormously popular in Australia and the UK, despite not having regulatory approval in any country. Its nickname in the Australian community is 'Barbie drug' for the tan it produces.

How it works

MT-2 binds to melanocortin receptors, particularly MC1R (melanogenesis), MC3R and MC4R (appetite and sexual function). MC1R activation triggers melanocytes to produce more melanin, darkening the skin with or without UV exposure (though UV exposure significantly enhances the effect). MC4R activation in the hypothalamus produces libido-enhancing effects and appetite suppression. The broad receptor binding is what gives MT-2 its multiple effects - but also its side effects, as melanocortin receptors are involved in numerous physiological processes.

Side effects

Research history

The mole concern

The most significant safety concern with MT-2 is its effect on moles and nevi. By stimulating melanogenesis globally, MT-2 can darken existing moles and potentially stimulate new mole growth. While there is no direct evidence that MT-2 causes melanoma, it could theoretically promote the growth of pre-existing melanocytic lesions. Australian dermatologists recommend: (1) getting a full mole check before starting, (2) monitoring all moles during use with monthly photos, (3) immediately stopping if any mole changes shape, colour, or border. Given Australia's high melanoma rate, this concern is particularly relevant for Australian users.

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References

1. [1]Dorr RT, et al. "Effects of a superpotent melanotropic peptide in combination with solar UV radiation on tanning of the skin in human volunteers." Archives of Dermatology, 2004.
2. [2]Hadley ME, Dorr RT. "Melanocortin peptide therapeutics: historical milestones, clinical studies and commercialization." Peptides, 2006.

Frequently asked questions

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