PT-141
Bremelanotide (PT-141)
The only FDA-approved peptide specifically for sexual dysfunction
PT-141 (Bremelanotide) is a melanocortin receptor agonist that works in the brain to increase sexual desire. It is FDA-approved as Vyleesi for hypoactive sexual desire disorder in women.
Admin routes
Subcutaneous
Popularity
Medium
Side effects
Generally mild
Vendors
5 rated
Key benefits
What to expect
Effects within 30–60 minutes; lasts 6–12 hours
Optimal dose found through titration (start low)
Used as-needed; no daily protocol required
Based on community reports and published research. Individual results vary significantly.
🏪Rated vendors
View all →Vendor ratings are based on community feedback and are not endorsements. Always verify third-party certificates of analysis (CoA) and check your local regulations before purchasing.
Dosing protocols
Sexual dysfunction
1.75 mg (FDA-approved dose)
As needed, 45 min before activity
As needed (max once per 24 hours)
Research / lower dose
500–1000 mcg
As needed
As needed
Dosing information is sourced from published research and community protocols. This is not a recommendation. Consult a healthcare professional.
Research status|FDA-approved (Vyleesi) - Phase 3 clinical data
Overview
PT-141 (Bremelanotide, brand name Vyleesi) was originally derived from Melanotan 2 research when scientists noticed MT-2's pronounced libido-enhancing effects. PT-141 was specifically optimised for sexual function, targeting MC4R receptors in the brain that regulate sexual arousal and desire. Unlike PDE5 inhibitors (Viagra, Cialis) which work on blood flow mechanics, PT-141 acts centrally - it increases desire and arousal rather than just enabling physical response. It was FDA-approved in 2019 for hypoactive sexual desire disorder (HSDD) in premenopausal women, making it the first peptide approved specifically for sexual dysfunction.
How it works
PT-141 activates melanocortin-4 receptors (MC4R) in the hypothalamus and limbic system - brain areas involved in sexual desire and arousal. This is fundamentally different from PDE5 inhibitors which work peripherally on blood vessel smooth muscle. By acting centrally, PT-141 increases desire (wanting) rather than just physical capability. It also has some MC1R activity (causing mild tanning) and MC3R activity (appetite effects), though these are less pronounced than with MT-2 due to its optimised receptor selectivity.
Side effects
Research history
Derived from Melanotan 2 research at University of Arizona
Phase 3 clinical trials for female sexual dysfunction begin
FDA approves bremelanotide (Vyleesi) for HSDD in women
Off-label use expands to male sexual dysfunction
Research into additional MC receptor-mediated applications
PT-141 vs Viagra/Cialis
The key difference is mechanism. Viagra and Cialis (PDE5 inhibitors) increase blood flow to erectile tissue - they enable the physical response but don't affect desire. PT-141 works in the brain to increase desire and arousal. This makes PT-141 effective in cases where PDE5 inhibitors fail, particularly when the issue is low desire rather than physical dysfunction. Some practitioners use PT-141 in combination with PDE5 inhibitors for patients with both low desire and erectile dysfunction.
Recommended products
Hand-picked for this compound. Ships via Amazon 🇺🇸
Core Supplies
Bacteriostatic Water 30mL
Storage & Transport
Portable Insulin Cooler Fridge
Further Reading
Peptide Protocols
References
- [1]Clayton AH, et al. "Bremelanotide for hypoactive sexual desire disorder in premenopausal women (RECONNECT)." Obstetrics & Gynecology, 2019.
- [2]Diamond LE, et al. "An effect on the subjective sexual response in premenopausal women with sexual arousal disorder by bremelanotide (PT-141)." Journal of Sexual Medicine, 2006.
Frequently asked questions
Related peptides
Community experiences
Share your experience with PT-141. Effects, side effects, protocol details - help others make informed decisions.
No community reviews yet. Be the first to share your experience with PT-141.
Need to calculate your dose?
Use our free reconstitution calculator to work out syringe units for PT-141.
Open CalculatorFound this useful?
Share this guide
Get the free Beginner Peptide Protocol
Which peptides to start with, what to avoid, and safe handling. Delivered to your inbox.
Vendors
Rated suppliers
Quality, shipping, and service scores
Store
Supplies
Syringes, bac water, storage
Guides
How-to guides
Storage, reconstitution, and travel
Disclaimer: This guide is for educational and informational purposes only. It is not medical advice. The dosing protocols listed are sourced from published research and community reports and do not constitute a recommendation. Always consult a qualified healthcare professional before using any peptide. Check your local regulations regarding peptide purchase and use.