DNSP-11
Dopamine Neuron Stimulating Peptide-11
GDNF-derived peptide targeting Parkinson's disease
DNSP-11 is an 11-amino-acid peptide derived from the proprotein region of GDNF (Glial Cell Line-Derived Neurotrophic Factor), developed as a potential treatment for Parkinson's disease.
Admin routes
Intranasal, Intracerebroventricular (research)
Popularity
Niche
Side effects
Generally mild
Vendors
0 rated
Key benefits
What to expect
No human dosing data. Animal studies showed neuroprotection over 2-4 weeks.
Based on community reports and published research. Individual results vary significantly.
Dosing protocols
Research reference (animal studies)
Varies by study
Daily in published protocols
2-4 weeks in animal studies
Dosing information is sourced from published research and community protocols. This is not a recommendation. Consult a healthcare professional.
Research status|Preclinical - animal models of Parkinson's disease
Overview
DNSP-11 was discovered by researchers at the University of Kentucky who identified that the pro-region of GDNF (the part normally cleaved off during processing) contains biologically active sequences. DNSP-11 specifically promotes the survival and function of dopaminergic neurons without requiring the full GDNF protein, which is too large to cross the blood-brain barrier easily. In animal models of Parkinson's disease, DNSP-11 preserved dopamine neuron function and improved motor outcomes. Its small size makes it a more practical therapeutic candidate than full-length GDNF.
How it works
DNSP-11 promotes dopaminergic neuron survival through mechanisms distinct from mature GDNF. While GDNF signals through the GFRalpha1/RET receptor complex, DNSP-11 appears to work through a different pathway. It increases dopamine levels, preserves tyrosine hydroxylase-positive neurons, and reduces oxidative stress in the substantia nigra. The exact receptor target is still being characterised.
Side effects
Research history
Bradley et al. publish identification and characterisation of DNSP-11
Recommended products
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Core Supplies
Bacteriostatic Water 30mL
Storage & Transport
Portable Insulin Cooler Fridge
Further Reading
Peptide Protocols
References
- [1]Bradley LH, et al. 'Dopamine neuron stimulating actions of a GDNF propeptide.' PLoS ONE, 2010.
Frequently asked questions
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Supplies
Syringes, bac water, storage
Guides
How-to guides
Storage, reconstitution, and travel
Disclaimer: This guide is for educational and informational purposes only. It is not medical advice. The dosing protocols listed are sourced from published research and community reports and do not constitute a recommendation. Always consult a qualified healthcare professional before using any peptide. Check your local regulations regarding peptide purchase and use.